Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
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چکیده
منابع مشابه
Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways.
Staurosporine has long been used in vitro as an initiator of apoptosis in many different cell types, but the mechanism involved remains poorly understood. In the present study, we have examined the apoptosis-inducing potential of staurosporine in cultured melanoma cell lines and dissected the staurosporine-induced apoptotic signaling pathway. We report that although staurosporine activated Bax ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2001
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1204436